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A mutation in the receptor binding site enhances

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An Insertion Mutation That Distorts Antibody Binding Site .

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody Article (PDF Available) in mBio 2(1):e00345-10 · December 2011 with 34 Reads

A Single Mutation at Position 190 in Hemagglutinin .

A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice Qiaoyang Teng, aDawei Xu, Weixia Shen, aQinfang Liu, Guangyu Rong, Xuesong Li, Liping Yan, Jianmei Yang,a,b Hongjun Chen,a Hai Yu,a Wenjun Ma,b Zejun Lia

A mutation in the receptor binding site enhances .

Q223R emerged during propagation in eggs and lies in the receptor binding site. We found that the Q223R mutation greatly enhanced infectivity of HA-pseudotypes in human cells, which was further augmented by inclusion of the viral neuraminidase (NA) and M2 proteins. Loss of glycosylation at residue 276 did not alter infectivity.

Epidermal growth factor receptor mutation enhances .

Epidermal growth factor receptor (EGFR) activation has been demonstrated to have a critical role in tumor angio- ... ATP for the tyrosine kinase binding site on the EGFR and the resulting inhibition of autophosphorylation blocks down-stream signaling (2). Gefitinib has minimal adverse effects, ... EGFR MUTATION ENHANCES VEGF EXPRESSION IN LUNG ...

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade .

Upon receptor activation, ... Our results showed that p65 could enrich the p50 binding site at −17 kb of Tgfβ1 promoter ... Thus, TMEM43 S358L mutation enhances the activation of NF-κB and TGFβ signaling, which results in the increasing fibrosis in the heart.

An Insertion Mutation That Distorts Antibody Binding Site .

The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the ...

Androgen receptor - Wikiped

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor[8] that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone[9] in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely ...

A mutation in the receptor binding site enhances .

A mutation in the receptor binding site enhances infectivity of 2009 H1N1 influenza hemagglutinin pseudotypes without changing antigenicity. Author links open overlay panel Wei Wang a Juan A. Castelán-Vega a 1 Alicia Jiménez-Alberto a 1 Russell Vassell a ...

An Insertion Mutation that Distorts Antibody Binding Site .

OSTI.GOV Journal Article: An Insertion Mutation that Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

Receptor binding specificity and origin of 2009 H1N1 .

HA protein on its binding affinity. Position 222 resides in the receptor binding site of the HA protein of 2009 H1N1 and therefore may play a critical role in HA bind-ing specificity. One of the findings in [7] indicated that mutation D222G in the HA of 2009 H1N1 enhances the selection for avian type receptors, and reduces the selec-

A Single Mutation at Position 190 in Hemagglutinin .

Further molecular and single mutation analysis revealed that a valine (V) residue at position 190 in HA is responsible for efficient replication of these H9N2 viruses in mice. The 190V in HA does not affect virus receptor binding specificity, but enhances binding affinity to human cells and lung tissues from mouse and human.

A Single Mutation in the Glycophorin A Binding Site of .

A Single Mutation in the Glycophorin A Binding Site of Hepatitis A Virus Enhances Virus Clearance from the Blood and Results in a Lower Fitness Variant ... Only when specific antibodies against the glycophorin A binding site were ... However, since it is not exactly the same receptor molecule, the binding efficiency is predicted to be low. Due ...

The Lurcher mutation of an α-amino-3-hydroxy-5-methyl-4 .

Request PDF on ResearchGate | The Lurcher mutation of an α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor subunit enhances potency of glutamate and converts an antagonist to an ...

T cell receptor signaling can directly enhance the avidity .

title = "T cell receptor signaling can directly enhance the avidity of CD28 ligand binding", abstract = "T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse.

Mutation of the 2(nd) Sialic Acid-Binding Site Resulting .

Here, we show that their N9 protein displays reduced binding to and lower enzymatic activity against multivalent substrates, resulting from mutation of the 2(nd) sialic acid-binding site. This mutation preceded and may have driven the selection of substitutions in H7 that modify H7 receptor-binding properties.

ERBB2 juxtamembrane domain (trastuzumab binding site) gene .

ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ERBB2 gene Skip to main content Thank you for visiting nature.com.

A mutation in the receptor binding site enhances .

Using lentiviral pseudotypes bearing influenza hemagglutinin (HA-pseudotypes) we evaluated a glutamine to arginine mutation at position 223 (Q223R) and glycosylation at residue 276 in HA for their effects on infectivity and neutralization. Q223R emerged during propagation in eggs and lies in the receptor binding site.

The 2nd sialic acid-binding site of influenza A virus .

Changes in the receptor-binding properties of the HA proteins are achieved by mutations in the receptor binding site, which have been well documented for several HA subtypes [1, 10, 11, 18]. Much less is known about the adaptations in NA required to match the corresponding HA proteins.

Naturally Occurring Mutations at the Acetylcholine .

By defining functional defects in a congenital myasthenic syndrome (CMS), we show that two mutant residues, located in a binding site region of the acetylcholine receptor (AChR) epsilon subunit, exert opposite effects on ACh binding and suppress channel gating. Single channel kinetic analysis reveals that the first mutation, εN182Y, increases ACh affinity for receptors in the resting closed ...

Galeterone Prevents Androgen Receptor Binding to Chromatin .

Galeterone Prevents Androgen Receptor Binding to Chromatin and Enhances Degradation of Mutant Androgen Receptor. Ziyang Yu, Changmeng Cai, Shuai Gao, ... Structural studies have shown that T878 in helix 9 of the AR ligand-binding domain sits in the steroid-binding pocket and that the T878A mutation provides more room in this pocket ...

A mutation in the receptor binding site enhances .

A mutation in the receptor binding site enhances infectivity of 2009 H1N1 influenza hemagglutinin pseudotypes without changing antigenicity ... the effect of this mutation on the receptor-binding ...